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6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3
JAK2 inhibitor AZD1480 inhibits JAK2 activation
33H2/b20-10+
CAS Number: 315704-66-6
ITF2357 (Givinostat) ate (Monocaprin) 6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3Givinostat or gavinostat, aslo known as ITF2357, is a potent and orally active histone deacetylase inhibitor with potential anti inflammatory, anti angiogenic, and antineoplastic activities. It is a hydroxamate used in the form of its hydrochloride. Inhibition of HDAC activity by ITF2357 ameliorates joint inflammation and prevents cartilage and bone destruction in experimental arthritis. ITF2357 reduces cytokines and protects islet cells in vivo and