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2011 Nov-Dec
selective and cell permeable inhibitor of SMARCA4 and PB1(5) bromodomains with IC50 ~ 89 nM and 48 nM respectively
CAS Number: 864814-88-0
the introduction of the boronic acid group confers superior oral bioavailability of GLL398 (AUC = 36
Foretinib 603oglibose 2011 Nov-DecForetinib, also known as XL880 and GSK1363089, is an orally bioavailable small molecule with potential antineoplastic activity. MET VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto oncogene c MET has been found to be over