RD162 ipine (hydrochloride) α-Glucosidase inhibitory effect of Potentilla

α-Glucosidase inhibitory effect of Potentilla astracanica and some isoflavones: Inhibition kinetics and mechanistic insights through in vitro and in silico studies

Smiles: CN(C)CC1=CC(=CC=C1)N/C(=C1/C2=CC=C(C=C2NC/1=O)C(N)=O)/C1C=CC=CC=1

2010 Sep 1

CAS Number: 917-13-5

RD162 ipine (hydrochloride) α-Glucosidase inhibitory effect of PotentillaIC50: 30. 9 nM RD162 is an androgen receptor (AR) antagonist. Metastatic prostate cancer is treated with drugs antagonizinf androgen action, but most patients progress to a more aggressive form of the disease named castration resistant prostate cancer, driven by elevated expression of the androgen receptor (AR). In vitro: RD162 was optimized from a screen for nonsteroidal antiandrogens retaining activity in the setting of increased androgen receptor