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O'Boyle Ii DR
InChi: InChI=1S/C23H24FN5O/c1-15(25)14-30-20-8-6-17(7-9-20)21-13-26-23-11-10-22(28-29(21)23)27-16(2)18-4-3-5-19(24)12-18/h3-13
with EC50s of 330 nM
indicating low clearance
PD-166793 2265 O'Boyle Ii DRPD 166793 is a potent, selective, orally active and widebroad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP 2, MMP 3 and MMP 13 (IC50=4, 7, and 8 nM, respectively) and micromolar potency vs MMP 1, 7 and 9 (IC50=6. 0, 7. 2, and 7. 9 M, respectively). PD 166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure. Product information CAS Number: 199850 67 4 Molecular Weight: 412. 30
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