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a Highly Selective Protein Interaction Inhibitor
PRMT1 Upregulated by Epithelial Proinflammatory Cytokines Participates in COX2 Expression in Fibroblasts and Chronic Antigen-Induced Pulmonary Inflammation
defined medium
including USP2
Bromosporine - Pan-bromodomain Inhibitor. CAS# 1619994-69-2 istone Demethylase a Highly Selective Protein InteractionBromosporine, CAS No. 1619994 69 2, is a broad spectrum inhibitor for bromodomains with IC50 of 0. 41 M, 0. 29 M, 0. 122 M and 0. 017 M for BRD2, BRD4, BRD9 and CECR2, respectively. In cell based assays, Bromosporine (1 M) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1, BAZ2A, and SMARCA2 (at 10 M). Bromosporine shows moderate cytotoxicity in HeLa cells at 18 M. It is a very useful chemical probe for bromodomain
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