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in a rat model of spatial learning and memory
InChiKey: CMOJHDQJJPIVEC-MNDPQUGUSA-N
Chemical Name: N-[(6-methyl-2-oxo-4-propyl-1
InChi: InChI=1S/C19H21ClFN3O4S/c1-11-14(21)5-2-6-15(11)23-19(26)24-16-8-7-13(20)18(17(16)25)29(27
A 943931 dihydrochloride l O-β-D-glucopyranoside in a rat model ofA 943931, is an H4R (one of histamine receptor subtypes) antagonist with high affinities to H4Rs of human (Ki = 5 nM), rat (Ki = 4 nM) and mouse (Kb = 6 nM) . H4R is one of 4 known G protein coupled receptors (H1, H2, H3 and H4 receptors) of histamine for histamine to mediate its physiological functions . HMC 1 cells incubated with A 943931 at a concentration of 300 nM for 20 min inhibited the increase in ALDH2 activity induced by H4R . In microglia,
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