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NSC624206 prevents in vitro ubiquitination of the cell cycle regulator p27 as well as inducing an accumulation of p27 in the HepG2 liver cancer cell line
InChi: InChI=1S/C6H2Cl4O2/c7-1-2(8)4(10)6(12)5(11)3(1)9/h11-12H
InChiKey: ISTCYDGUBPNUDF-CQSZACIVSA-N
InChi: InChI=1S/C26H32N4O8/c31-21(9-13-29-24(34)7-8-25(29)35)27-12-16-38-18-17-37-15-11-22(32)28-20-4-1-19(2-5-20)3-6-23(33)30-14-10-26(30)36/h1-2
CBR-470-1 arbonyltopsentin NSC624206 prevents in vitro ubiquitinationCBR 470 1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR 470 1 is also a non covalent Nrf2 activator. CBR 470 1 protects SH SY5Y neuronal cells against MPP+ induced cytotoxicity through activation of the Keap1 Nrf2 cascade. Product information CAS Number: 2416095 06 0 Molecular Weight: 365. 90 Formula: C14H20ClNO4S2 Chemical Name: (3R,4S) 3 (4 chlorobenzenesulfonyl) 4 [(2 methylpropyl)amino] 1 thiolane 1,1 dione Smiles:
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