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550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection
Multiple myeloma (MM) lines
3-3 μM) dose-dependently reduces the migration of cells induced by growth factors (PDGF-BB
(2013) ACS Med Chem Lett
Tivantinib previr 550: a potent and selectiveTivantinib (ARQ 197) is an orally bioavailable small molecule inhibitor of c Met with potential antineoplastic activity. c Met inhibitor ARQ 197 binds to the c Met protein and disrupts c Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c Met protein or expressing consitutively activated c Met protein. c Met protein, the product of the proto oncogene c Met, is a receptor tyrosine kinase also known as
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