NNGH - CAS# 161314-17-6 798CG-100602 4 hours) moderately reduces LPS-induced

4 hours) moderately reduces LPS-induced IL-6 and IFN-b expression in the J774 cell at 10 μM

InChi: InChI=1S/C15H20ClN3O2/c1-14(2

JNJ16259685 (30 mg/kg) produces very minimal effects on locomotor activity

CAS Number: 755038-65-4

NNGH - CAS# 161314-17-6 798CG-100602 4 hours) moderately reduces LPS-inducedKi: 9, 2. 6, 4. 3, 3. 1, and 17 nM for MMP 8, 9, 12, 13, and 20, respectively. NNGH is an inhibitor of MMPs. Matrix metalloproteinases (MMPs), a large class of strictly related zincdependent enzymes, belong to the family of proteolytic enzymes. MMPs are involved in various aspects of physiological cellular processes and pathologies, such as pulmonary emphysema, reumathoid arthritis, tumor growth and metastasis. In vitro: Previous study found that NNGH