Platensimycin e chloride hydrate 4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-1H

4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-1H

CAS Number: 1807530-06-8

InChiKey: VBGNJMUEMDYZJJ-HGKIGUAWSA-N

perindopril erbumine is converted to its active form perindoprilat

Platensimycin e chloride hydrate 4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-1HPlatensimycin is an antibiotic produced by S. platensis that inhibits gram positive bacteria by selectively inhibiting cellular lipid biosynthesis (IC50=0. 1 M). Platensimycin targets the ketoacyl acyl carrier protein synthase I II, FabF B, an enzyme that participates in the biosynthesis of fatty acids (IC50s=48 nM and 160 nM for S. aureus and E. coli enzymes, respectively). Platensimycin is a promising agent for overcoming antibiotic resistance.