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and has the potential in targeting eIF4E for solid cancers
2018 Mar 1
5-dihydroxyphenyl)ethenyl]-N'-hydroxybenzene-1-carboximidamide
orally bioavailable and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor
BIBS 39 odoHoechst 33258 and has the potential inBIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. Target: Angiotensin Receptorin vitro: BIBS 39 displaces [125I] AII from its specific binding sites with a Ki value of 29 7 nM for the AII subtype 1 (AT1) receptor and a Ki value of 480 110 nM for the AII subtype 2 (AT2) receptor. BIBS 222 shows a Ki value of 20 7 nM for the AT1 subtype and a Ki value of 730 170 nM for the AT2 subtype. BIBS 39 is 17 times more selective for the AT1
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