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CAS Number: 1127498-03-6
ABC-294640
708±83 mm3
InChiKey: UJHBVMHOBZBWMX-UHFFFAOYSA-N
JNJ-31020028 Catalog No.:M10404-2 CAS Number: 1127498-03-6JNJ 31020028 is a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. JNJ 31020028 bound with high affinity (pIC(50) = 8. 07 + 0. 05, human, and pIC(50) = 8. 22 + 0. 06, rat) and was >100 fold selective versus human Y(1), Y(4), and Y(5) receptors. JNJ 31020028 was demonstrated to be an antagonist (pK(B) = 8. 04 + 0. 13) in functional assays. JNJ 31020028 occupied Y(2) receptor binding sites (approximately 90% at 10
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